Engineering small molecules that nucleate assembly of protein complexes

Applications of Small Molecules in Muscle Tissue Engineering

Introduction: Skeletal muscles account for about 40% of the total body weight. Every year, hundreds of people lose at least part of their muscle tissue due to illness, war, and accidents. This can lead to disruption of activities such as breathing, movement, and social life. To this end, various therapeutic strategies such as medication therapy, cell therapy and tissue transplantation have been...

-tubulin Complexes that Differ in Their Ability to Nucleate Microtubules

g -tubulin exists in two related complexes in Drosophila embryo extracts (Moritz, M., Y. Zheng, B.M. Alberts, and K. Oegema. 1998. J. Cell Biol. 142:1– 12). Here, we report the purification and characterization of both complexes that we name g -tubulin small complex ( g TuSC; z 280,000 D) and Drosophila g TuRC ( z 2,200,000 D). In addition to g -tubulin, the g TuSC contains Dgrip84 and Dgrip91,...

small molecules as protein-proteininteraction inhibitors

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Discovery of Small Molecules that Inhibit the Disordered Protein, p27Kip1

Disordered proteins are highly prevalent in biological systems, they control myriad signaling and regulatory processes, and their levels and/or cellular localization are often altered in human disease. In contrast to folded proteins, disordered proteins, due to conformational heterogeneity and dynamics, are not considered viable drug targets. We challenged this paradigm by identifying through N...

INTERACTION OF PROTEINS WITH SMALL MOLECULES